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STAT TRANSCRIPTION FACTORS
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DeCS
Descriptor
English
:
STAT Transcription Factors
Descriptor
Spanish
:
Factores de Transcripción STAT
Descriptor
Portuguese
:
Fatores de Transcrição STAT
Tree Number:
D12.644.360.024.342
D12.776.157.057.186
D12.776.476.024.421
D12.776.930.840
Definition
English
:
A
family
of
transcription factors
containing SH2 DOMAINS that are involved in CYTOKINE-mediated
SIGNAL TRANSDUCTION
.
STAT transcription factors
are recruited to the cytoplasmic region of CELL SURFACE RECEPTORS and are activated via
PHOSPHORYLATION
. Once activated they dimerize and translocate into the
CELL NUCLEUS
where they influence
GENE expression
. They play a
role
in regulating
CELL GROWTH PROCESSES
and
CELL DIFFERENTIATION
.
STAT transcription factors
are inhibited by
SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS
and
PROTEIN INHIBITORS OF ACTIVATED STAT.
Indexing Annotation
English
:
general; prefer specifics
History Note
English
:
2006
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
50795
Unique Identifier:
D050791
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS